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duce the spread of Gram-negative bacteria.1 Meta-analyses have found that many nonpharmacologic interventions can significantly reduce the rate of ventilator-associated pneumonia; these include kinetic bed therapy, subglottic secretion drainage, heatand-moisture exchangers (rather than heated humidifiers), and oral decontamination with chlorhexidine.6 Environmental controls can prevent a large percentage of hospital-acquired bacterial infections. Fewer nosocomial infections will reduce overall antibiotic use, which should reduce the risk of creating bacterial antibiotic resistance and improve the efficacy of antibiotics given to patients who do acquire infections. Much more research is needed on the prevention and antibiotic treatment of Gram-negative infections.